胶质瘤
荧光
体内
纳米医学
生物相容性
体内分布
生物物理学
材料科学
化学
癌症研究
纳米技术
生物化学
体外
生物
纳米颗粒
有机化学
量子力学
物理
生物技术
作者
Min Zheng,Shaobo Ruan,Shi Liu,Tingting Sun,Dan Qu,Haifeng Zhao,Zhigang Xie,Huile Gao,Xiabin Jing,Zaicheng Sun
出处
期刊:ACS Nano
[American Chemical Society]
日期:2015-10-16
卷期号:9 (11): 11455-11461
被引量:428
标识
DOI:10.1021/acsnano.5b05575
摘要
A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using d-glucose and l-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood–brain barrier and precisely targeting glioma tissue. However, its counterparts, the CDs synthesized from d-glucose (CD-G), l-asparic acid (CD-A), or d-glucose and l-glutamic acid (CD-Glu) have no or low selectivity for glioma. Therefore, CD-Asp could act as a fluorescence imaging and targeting agent for noninvasive glioma diagnosis. This work highlights the potential application of CDs for constructing an intelligent nanomedicine with integration of diagnostic, targeting, and therapeutic functions.
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