Parallel studies on the effect of anti-lymphocytic antibody on cell mediated and humoral antibody responses in the rat.

The effect of prolonged treatment with anti-lymphocytic IgG raised in horses on cell mediated (homograft rejection) and humoral type immune responses has been investigated simultaneously in the same animal. The rejection of skin homografts precedes the development of circulating antibodies against alum precipitated bovine serum albumin but may follow the formation of agglutinating antibodies against sheep erythrocytes. High levels of antibodies against horse IgG are frequently detected prior to graft rejection.