On the design of urokinase labile prodrugs. Effects of surfactants on surface adsorption of urokinase and comparison of methods for the determination of KM and kcat.

Etude comparative de l'efficacite de surfactants, tween 80, Triton X-100, PEG 6000, albumine et gelatine, sur l''inhibition de l'adsorption de l'urokinase. Activite et stabilite de l'enzyme vis-a-vis de l'activation des pro-medicaments tels que les dextrans