Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB).DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects.and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.The IL-6 -572 C/C and IL-10 -819 T/T genotypes were observed less frequently in the case group than in the control group, with crude odds ratios of 0.591 [95% confidence interval (CI) = 0.381-0.917]and 0.401 (95%CI = 0.257-0.627),respectively.A significant association remained after adjusting for environmental factors in multivariate logistic analysis.The homozygote genotypes ©FUNPEC-RP www.funpecrp.com.