Synthesis of trazodone hydrochloride

Trazodone hydrochloride was synthesized from 2 chloropyridine via substitution with hydrazine hydrate,cyclocondensation with urea,condensation with 1 (3 chlorophenyl) 4 (3 chloropropyl) piperazine monohydrochloride in the presence of alkali,and then treatment with hydrochloride The overall yield was 39%,and the target compound was identified by spectroscopic analysis The condensation reaction,in which sodium hydroxide was used instead of sodium hydride,was more moderate and easier to operate.