Nanjing-Hangzhou expressway Xueba highway suspension bridge is a tower-beam consol-idated self-anchored suspension bridge with double towers and double cable planes. Its structure is novel and beautiful. Taking Xueba highway suspension bridge for example, the process and key points of the main cable alignment monitoring, which is one of the most important monitoring methods for self-anchored suspension bridge, are introduced. It provides some reference for the construction and monitoring of similar bridges.