Thyroid function and thyroid autoantibodies in patients with Hashimoto's thyroiditis

ObjectiveTo investigate the serum concentration of TT_4, FT_4, TT_3, FT_3, h-TSH, TPOAb and TgAb,and the relationship among h-TSH and TPOAb, TgAb in patients with Hashimoto's thyroiditis. Methods One hundred and six patients with Hashimoto's thyroiditis and 110 controls were recruited in this study. Serum TT_4, FT_4, TT_3 FT_3, h-TSH, TPOAb and TgAb were measured in the two groups. Results There were significant differences between the controls and the patients in serum concentration of h-TSH, TPOAb, TgAb and TT_4. Correlation analysis demonstrated that no significant correlation was found among the serum concentrations of h-TSH and TPOAb, TgAb (P=0.818, 0.774 respectively). Conclusion The patients with Hashimoto's thyroiditis had a lower serum level of TT_4, and higher level of h-TSH, TPOAb and TgAb. High concentration of two autoantibodies in patients with Hashimoto's thyroiditis suggested that humoral immunity maybe a critical progress in this disease. To measure serum level of TPOAb and TgAb can be helpful to screen Hashimoto's thyroiditis and to differentiate it from other thyroiditis.