ESBLs-producing Gram-negative Bacteria in Senile Patients: A Clinical Investigation

OBJECTIVE To study the infection condition of extended-spectrum β-lactamases(ESBLs) -producing Gram-negative bacilli in senile patients for reasonable use of antibiotics in clinic. METHODS The double-disk synergy test was performed to detect ESBLs-producing strains and 17 antibiotics were determined by the antimicrobial disk diffusion susceptibility tests in specimen collected from 741 senile patients. RESULTS The total rate of ESBLs-producing Gram-negative bacilli in senile patients was 28.7%. All strains of ESBLs were susceptible to imipenem and cefoperazone/ sulbactam(100%). CONCLUSIONS Imipenem and cefoperazone/ sulbactam were better for the infection caused by ESBLs-producing Gram-negative bacilli in senile patients.