Analysis on Clinical Efficacy and Safety of Pioglitazone Combined with Metformin in the Treatment of Type 2 Diabetes

OBJECTIVE:To analyze clinical efficacy and safety of pioglitazone combined with metformin in the treatment of type 2 diabetes.METHODS:102 patients with type 2 diabetes were randomly divided into 2 groups.Treatment group received pioglitazone combined with metformin and treatment group received metformin alone.The levels of blood glucose and insulin were observed and compared between 2 groups.RESULTS:After 6 months of treatment,fasting plasma glucose(FPG),postprandial 2 h blood glucose(P2hBG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS),postprandial 2 h insulin(P2hINS),steady-state assessment index of insulin(HOMA-IR) in 2 groups were significantly decreased,there was statistical significance in difference before and after treatment(P0.05).After treatment,the level of FPG,P2hBG,HbA1c,FINS,P2hINS and HOMA-IR in treatment group was significantly lower than in control group,there was statistical significance(P0.05);There were few adverse drug reactions,and no serious adverse drug reaction was observed.CONCLUSION:Pioglitazone combined with metformin can significantly lower the level of blood sugar and improve insulin index in patients with type 2 diabetes with few adverse drug reactions.