IL-1α PROMOTES THE BONE RESORPTION INDUCED BY THE OSTEOCLASTLIKE CELL SEPARATED FROM THE GIANT CELL TUMOUR OF BONE

Objective: To compare the function of bone resorption by the multinucleated giant cell (MGC) separated from giant cell tumour(GCT) with the osteoclast. Methods: The multinucleated giant cells (MGC) were separated from giant cell tumour and cultured with bone slice. The effect of IL-1α(50 μg/L, 100 μg/L)on bone resorption by MGC was observed. Results: IL-1α enchanced the numbers and the area of bone resorption lacunae on bone slices and it was dosedepended. MGC could maintain the ability of bone resorption over a long period(1 month). Conclusion: IL-1α promotes bone resorption induced by MGC. The MGC does have the same function of bone resorption as the osteoclast.