Studies on Elimination Rule of Residues of Three Kinds of Quinolones in Eggs

A method for determination of quinolones residues in eggs by HPLC with fluorescence detector detection was established,and this method for determination the concentration in the laying hens,the elimination of quinolones residues in eggs was studied. Different content of norfloxacin,ofloxacin,enrofloxacin were added in the water for 3 days,the residues of quinolones were determined by HPLC. The results showed that the residues of norfloxacinand and ofloxacin in eggs were less than 10 μg / kg at 8th withdrawal day; the residues of enrofloxacin in eggs was less than 10 μg / kg at 12th withdrawal day. So,the withdrawal period of norfloxacin,ofloxacin, enrofloxacin were found to be 10 d,10 d,14 d in clinical before the age at first egg,respectively.