Advances of study in affecting factors of tumor radiosensitivity

OBJECTIVE:To summarize the progress in the research of tumor radiosensitivity and its mechanism.METHODS:A total of 1 209 papers were searched with radiosensitivity,cancer and radiotherapy as key words in PubMed and CNKI database from 1999-01 to 2011-11.The inclusion criteria: 1) relevant factors that influenced radiosensitivity;2) mechanisms research of the regulation of radiosensitivity;3) drugs,methods and sensitization therapy that influence radiosensitivity.According to the choice criteria,40 papers were selected and analyzed.RESULTS: Radiosensitivity can be influenced both by factors intrinsic and extrinsic.Some relevant factors that influenced radiosensitivity such as hypoxia,cell cycle,DNA damage and repair,apoptosis etc.Besides,mutation or polymorphism or epigenetic modification of genes which were associated with the biological effects of radiation,could result in radiosensitivity difference.CONCLUSION:Deep research in radiosensitivity means extraordinary significant for prediction the curative effect and selection of individualized treatment.