血清素
色氨酸羟化酶
神经递质
5-羟色胺受体
海马体
单胺氧化酶
单胺类神经递质
内科学
内分泌学
化学
神经科学
受体
心理学
生物
医学
酶
生物化学
5-羟色胺能
作者
Haijuan Li,Rui-yun Peng,Changzhen Wang,Si-Mo Qiao,Zou Yong,Ya-bing Gao,Xinping Xu,Shaoxia Wang,Ji Dong,Hongyan Zuo,Zhao Li,Hongmei Zhou,Lifeng Wang,Xiangjun Hu
标识
DOI:10.1016/j.physbeh.2014.12.039
摘要
The increased use of microwaves raises concerns about its impact on health including cognitive function in which neurotransmitter system plays an important role. In this study, we focused on the serotonin system and evaluated the long term effects of chronic microwave radiation on cognition and correlated items. Wistar rats were exposed or sham exposed to 2.856GHz microwaves with the average power density of 5, 10, 20 or 30mW/cm(2) respectively for 6min three times a week up to 6weeks. At different time points after the last exposure, spatial learning and memory function, morphology structure of the hippocampus, electroencephalogram (EEG) and neurotransmitter content (amino acid and monoamine) of rats were tested. Above results raised our interest in serotonin system. Tryptophan hydroxylase 1 (TPH1) and monoamine oxidase (MAO), two important rate-limiting enzymes in serotonin synthesis and metabolic process respectively, were detected. Expressions of serotonin receptors including 5-HT1A, 2A, 2C receptors were measured. We demonstrated that chronic exposure to microwave (2.856GHz, with the average power density of 5, 10, 20 and 30mW/cm(2)) could induce dose-dependent deficit of spatial learning and memory in rats accompanied with inhibition of brain electrical activity, the degeneration of hippocampus neurons, and the disturbance of neurotransmitters, among which the increase of 5-HT occurred as the main long-term change that the decrease of its metabolism partly contributed to. Besides, the variations of 5-HT1AR and 5-HT2CR expressions were also indicated. The results suggested that in the long-term way, chronic microwave exposure could induce cognitive deficit and 5-HT system may be involved in it.
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