树枝状大分子
药物输送
生物相容性材料
纳米技术
药品
阿霉素
化学
抗癌药
药理学
材料科学
医学
生物医学工程
化疗
有机化学
外科
作者
Elizabeth R. Gillies,Jean M. J. Fréchet
标识
DOI:10.1016/s1359-6446(04)03276-3
摘要
The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and well-defined molecular weight, make them promising new scaffolds for drug delivery. In the past decade, research has increased on the design and synthesis of biocompatible dendrimers and their application to many areas of bioscience including drug delivery, immunology and the development of vaccines, antimicrobials and antivirals. Recent progress has been made in the application of biocompatible dendrimers to cancer treatment, including their use as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutron capture therapy and photodynamic therapy.
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