细胞凋亡
发病机制
心力衰竭
信号转导
医学
生物
癌症研究
免疫学
生物信息学
细胞生物学
内科学
遗传学
作者
Peter M. Kang,Seigo Izumo
标识
DOI:10.1016/s1471-4914(03)00025-x
摘要
Apoptosis has been implicated in both acute and chronic heart diseases. The loss of myocardium is an important pathogenic process in heart and, hence, the inhibition of apoptosis is a promising therapeutic option. Significant progress has been made in demonstrating the role of apoptosis in various heart diseases, and in elucidating the molecular mechanisms of cardiac apoptosis. In addition, the effects of various hypertrophic signaling molecules on apoptosis have been characterized. However, the significance of apoptosis to the overall pathogenesis of heart failure, and the relationship between cardiac hypertrophic signaling and apoptosis still needs further investigation.
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