Current separative strategies used for resveratrol determination from natural sources

Resveratrol, occurring as trans- and cis- isomeric forms, is a phytoalexin existing in grape vines, as well as the product, wine, and a large number of plants. Owing to its diverse pharmacological activities, including anticancer and anti-cardiovascular disease activity as well as life span increasing properties, quantification methods of resveratrol are evolving rapidly, including high-performance liquid chromatography (HPLC) coupled with various detectors, gas chromatography-mass spectrometry (GC-MS) and capillary electrophoresis (CE) related techniques. In the present review, our interests are focused on analytical methods of resveratrol determination based on separative techniques, and the advantages and disadvantages of each method are summarized and compared.