Controlled Trifluoromethylation Reactions of Alkynes through Visible‐Light Photoredox Catalysis

Abstract The control of a reaction that can form multiple products is a highly attractive and challenging concept in synthetic chemistry. A set of valuable CF 3 ‐containing molecules, namely trifluoromethylated alkenyl iodides, alkenes, and alkynes, were selectively generated from alkynes and CF 3 I by environmentally benign and efficient visible‐light photoredox catalysis. Subtle differences in the combination of catalyst, base, and solvent enabled the control of reactivity and selectivity for the reaction between an alkyne and CF 3 I.