医学
乳腺癌
前哨淋巴结
淋巴
转移
肿瘤科
淋巴结
哨兵节点
腋窝淋巴结
癌症
转移性乳腺癌
内科学
放射科
病理
作者
Khimara Naidoo,Sarah Pinder
标识
DOI:10.1016/j.surge.2016.07.002
摘要
Pathologists typically examine the sentinel lymph nodes excised from patients with invasive breast cancer more thoroughly than they have historically those from axillary lymph node clearance specimens. This, it is thought, increases the chances of detecting small metastatic foci (i.e. macrometastases (>2 mm), micrometastases (0.2–2 mm), or isolated tumour cell clusters (<0.2 mm or <200 cancer cells in one section)). However, the clinical significance of these small metastatic deposits remains unclear. Although an increasing nodal burden is known to proportionally decrease patient survival, the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial has, at the least, raised questions as to how best to manage nodal metastasis in early invasive breast cancer. These issues, and a brief overview of the biology of metastatic spread are presented in this review.
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