增粘剂
乙二醇
透明质酸
自愈水凝胶
化学
骨关节炎
地塞米松
药理学
活性氧
氧化应激
胶束
炎症
体内
右旋糖酐
抗氧化剂
PEG比率
生物化学
医学
免疫学
有机化学
内科学
财务
关节内
替代医学
水溶液
经济
生物技术
病理
解剖
生物
作者
Tong Zhou,Hao Xiong,Shuqin Wang,Haolan Zhang,Weiwei Zheng,Zhongru Gou,Cunyi Fan,Changyou Gao
标识
DOI:10.1016/j.mtnano.2021.100164
摘要
Selective exhaustion of over-expressed reactive oxygen species (ROS) is of great significance in the therapy of osteoarthritis (OA) because of the inhibiting effect on oxidative stress and inflammation. Herein, a ROS-scavenging and drug-release platform was prepared via encapsulating dexamethasone acetate (DA)-loaded ROS erasable poly(ethylene glycol)-b-polythioketal-b-poly(ethylene glycol) (PEG-PTK-PEG) micelles (PDM) into an injectable hydrogel. The hydrogel ([email protected]) was constructed by Schiff base reaction between hydrazide-grafted hyaluronic acid (HA-ADH) and aldehyde-modified dextran (Dex-ALH), achieving a self-healing property for viscosupplementation. The PDM imparted enhanced antioxidant capability to the hydrogel, which, in turn, endowed the PDM with prolonged retention and sustained DA release. The intraarticularly administered multifunctional injectable hydrogel potently diminished inflammation via depleting ROS and suppressing inflammatory cytokines, as well as downregulating pro-inflammatory M1 macrophages ratio in a rat OA model. The developed therapeutic system significantly alleviated OA symptoms, embodying the excellent capability of preventing cartilage extracellular matrix degeneration with negligible toxicity in vivo.
科研通智能强力驱动
Strongly Powered by AbleSci AI