Surface molecularly imprinted magnetic MOFs: A novel platform coupled with magneto electrode for high throughput electrochemical sensing analysis of oxytetracycline in foods

In order to solve inherent problems of traditional molecularly imprinted electrochemical sensors (MIECS), a novel platform of surface molecularly imprinted magnetic metal-organic frameworks ([email protected]) was coupled with magneto electrode to establish magnetic MIECS for the recognition of oxytetracycline (OTC). [email protected] were synthesized using layer-by-layer modification method for the recognition of OTC. With the help of magneto electrodes, [email protected] can be magnetically modified on the electrode surface, forming the electrochemical sensing interface. The imprinted cavities of [email protected] can act as the electron channel of the probe to realize label-free detection of OTC. A linear response was obtained within the OTC concentration range of 1.0 × 10−9 g mL−1-1.0 × 10−4 g mL−1. The applicability of the sensor was estimated using the spiking and recovery method in milk samples with the recoveries ranging from 89.0% to 103.1%. It has potential applications in food safety analysis with high throughput detection capability, high specificity and good stability.