Recent advance on microsomal triglyceride transfer protein

The microsomal triglyceride transfer protein (MTP) which was originally isolated form the microsomal fraction of bovine liver, accelerates the transport of triglyceride (TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between synthetic membranes. The protein was subsequently found within the lumen of microsomes isolated form both liver and intestine. The tissue distribution with its ability to transport TG, led to the hypothesis that MTP is involved in the assembly of plasma lipoprotein, very low density lipoprotein (VLDL) and chylomicrons (CM).