Research Progress on the Macrocycle-Derived Artificial Transmembrane Ion Channels

Macrocycles such as cyclodextrin and crown ether are applied to construct artificial transmembrane ion transport systems owing to their unique cavity structure and the ability to recognize molecules and ions via host-guest interaction.Compared with natural channel proteins, macrocycles have many advantages, such as the low cost, stabilities, easy structural modification and functionalization, etc., which make them preferable candidates for preparing artificial ion channel.Herein, we reviewed the recent progress of macrocycles-based artificial ion channels, and systematically summarized the preparation methods, structural regulation and potential applications of the artificial ion channels based on different macrocycles.Finally, we have briefly summarized and outlooked the progress of macrocycle-based artificial ion channels.This review is of great significance for developing novel artificial transmembrane ion channels and exploring their potential applications.