医学
CTLA-4号机组
封锁
抗体
肿瘤科
内科学
癌症
PD-L1
临床研究阶段
免疫系统
癌症研究
免疫疗法
免疫学
化疗
T细胞
受体
作者
David M. O’Malley,Maryna Neffa,Bradley J. Monk,Tamar Melkadze,Anna Kryzhanivska,Iurie Bulat,Tarek Meniawy,Igor Bondarenko,W.I. Ortuzar Feliu,Marek Ancukiewicz,Iwona Ługowska
标识
DOI:10.1016/j.annonc.2021.08.1167
摘要
Second-line treatment for R/M CC continues to present a major clinical challenge. Dual blockade of the PD-1 and CTLA-4 immune checkpoints is a validated therapeutic strategy for multiple malignancies. Here we present mature findings of a large single arm Phase II study evaluating the safety and antitumor activity of the anti-PD-1 antibody balstilimab (bal) plus the anti-CTLA-4 antibody zalifrelimab (zal) in pts with R/M CC.
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