Relationship between PI3K Mutation and Sodium-Iodide Symporter in Anaplastic Thyroid Carcinoma

The sodium-iodide symporter is a transmembrane protein that has important role in radio-iodide therapy in various cancers such as anaplastic thyroid carcinoma. Anaplastic thyroid carcinoma is a rare undifferentiated thyroid tumor, but highly aggressive and lethal malignancy. Usually it is resistant to radio-iodide therapy and a cause of this appearance knows through dysfunction of the sodium-iodide symporter. Some genomic mutations, like PI3K gene mutations, can affect on sodium-iodide symporter functions. This review article explains briefly about PI3K signaling pathway and survey its gene mutations in carcinomas especially in anaplastic thyroid carcinoma and its influence on sodium-iodide symporter and iodide uptake.