耐受性
医学
化疗
内科学
营养不良
生活质量(医疗保健)
结直肠癌
癌症
二十碳五烯酸
不利影响
护理部
多不饱和脂肪酸
有机化学
化学
脂肪酸
作者
Joan Trabal,Pere Leyes,Maria Forga,Joan Maurel
出处
期刊:PubMed
日期:2011-02-22
卷期号:25 (5): 736-40
被引量:20
摘要
To assess the effect of an intervention with an Eicosapentaenoic Acid-enriched oral nutritional supplement on chemotherapy tolerability in patients with advanced colorectal cancer.Thirteen patients diagnosed with stage IV colorectal cancer were included. Patients in the experimental group received 2 packs of supplement per day during 12 weeks plus dietary counseling. The control group only received dietary counseling. Patients were assessed for nutritional status, dietary intake, health related quality of life (HRQOL) and chemotherapy compliance.Only patients in the supplemented group significantly increased their weight after the intervention. They also had better scores in important domains of HRQOL, compared to controls. Although not statistically significant, the supplemented group did not experience interruptions in their chemotherapy treatment compared to the control group, with more interruptions due to toxicity.The present study, although limited by sample size, points out towards a positive effect of the intervention on chemotherapy tolerability.
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