格列齐特
药物输送
药理学
药品
化学
溶解度
格列吡嗪
输送系统
吸收(声学)
剂型
流出
胰岛素
医学
材料科学
内科学
生物化学
有机化学
复合材料
作者
Rajendra Awasthi,Giriraj T. Kulkarni
标识
DOI:10.3109/03639045.2013.763817
摘要
Aim: The current communication deals with the development of hollow floating beads of gliclazide. The primary effect of this drug is to potentiate glucose-stimulated insulin release from pancreatic islet-β-cells by induction of a decrease in potassium efflux from these cells. Because of the poor aqueous solubility, its absorption is limited. Thus, an attempt was made to improve its release profile.
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