Background: For in-hospital cardiac arrest (IHCA) patients, the early warning system is crucial to detect this critical condition in advance. However, there were limited publications to apply early warning information system on reducing IHCA. The aim of this study is to investigate the impact of early warning information system on reducing IHCA. Methods: Total 181,169 consecutive patients admitted to a tertiary medical center between January 2013 and November 2016 were enrolled in this study. An electronic national early warning score information system was established. Furthermore, according ROC curve, early warning score ≥7 or more than highest scores among previous 3 measurements were identified as quality index to detect critical patients. The physicians could manage critical patients early once computer-based reminding alarm noted. All patients were divided into 3 groups according to duration: before intervention (Jan 2013 to April 2015; n=707,957 patient-day), during intervention (May to June 2015; n=52,687 patient-day) and after intervention (July 2015 to November 2016; n=423,241 patient-day).