血管生成
基质凝胶
脐静脉
体内
药理学
激酶插入结构域受体
血管内皮生长因子
新生血管
成纤维细胞生长因子
化学
受体
癌症研究
生物
体外
生物化学
血管内皮生长因子A
血管内皮生长因子受体
生物技术
作者
Sang-Hyeon Nam,Khaliunaa Lkhagvasuren,Hee Seo,Jin-Soo Kim
摘要
Ziyuglycoside II, a major bioactive compound of Sanguisorba officinalis L., displays anticancer potential against several human cancer cells. However, little information concerning its antiangiogenic properties and possible mechanisms is available. The aim of this study was to investigate the inhibitory effects of ziyuglycoside II on angiogenesis. Ziyuglycoside II inhibited the proliferation, migration, and tubule formation of human umbilical vein endothelial cells, as well as the number of microvessels growing from the aortic rings. The underlying antiangiogenic mechanism of ziyuglycoside II correlated with blocking vascular endothelial growth factor receptor-2 and the fibroblast growth factor receptor-1 mediated signaling pathway. Moreover, an in vivo Matrigel plug assay in mice showed a significant decrease in vascularization and hemoglobin content in the plugs from ziyuglycoside II-treated mice compared with control mice. Overall, these results suggest that ziyuglycoside II inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects. Copyright © 2017 John Wiley & Sons, Ltd.
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