化学
计算生物学
药物发现
人类免疫缺陷病毒(HIV)
氮原子
药品
抗病毒药物
组合化学
病毒学
生物化学
药理学
生物
有机化学
群(周期表)
作者
. Urvashi,Jaya Kumar,Parthasarathi Das,Vibha Tandon
标识
DOI:10.1021/acs.jmedchem.2c00444
摘要
The azaindole (AI) framework continues to play a significant role in the design of new antiviral agents. Modulating the position and isosteric replacement of the nitrogen atom of AI analogs notably influences the intrinsic physicochemical properties of lead compounds. The intra- and intermolecular interactions of AI derivatives with host receptors or viral proteins can also be fine tuned by carefully placing the nitrogen atom in the heterocyclic core. This wide-ranging perspective article focuses on AIs that have considerable utility in drug discovery programs against RNA viruses. The inhibition of influenza A, human immunodeficiency, respiratory syncytial, neurotropic alpha, dengue, ebola, and hepatitis C viruses by AI analogs is extensively reviewed to assess their plausible future potential in antiviral drug discovery. The binding interaction of AIs with the target protein is examined to derive a structural basis for designing new antiviral agents.
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