New metabolites, 2,4,6-triketosuberic acid and 2,4,6,8-tetraketosebacic acid, formed from 2-butyne-1,4-diol by Fusarium merismoides B11.

New acidic products were isolated from the culture fluid of Fusarium merismoides B11 after growth on 2-butyne-1, 4-diol. These products were identified as 2, 4, 6-triketosuberic acid, HOOC-CH2COCH2COCH2CO-COOH, 2, 4, 6, 8-tetraketosebacic acid, HOOC-CH2-COCH2COCH2COCH2CO-COOH, and phthalic acid from their NMR, IR, UV, and MASS spectra, and elementary analyses. These polyketides, which are new metabolites, seem to be related to the biosynthesis of phthalic acid.