无血性
心理学
萧条(经济学)
构造(python库)
特质
临床心理学
临床前研究
神经科学
病因学
医学
精神科
多巴胺
计算机科学
宏观经济学
经济
程序设计语言
作者
Catherine Kelly,Kevin B. Freeman,Julie A. Schumacher
标识
DOI:10.1016/j.neubiorev.2022.104578
摘要
In our clinical work with treatment-resistant depressed (TRD) patients, certain patterns have emerged in terms of patients' presentations of anhedonia. Multiple studies have investigated anhedonia either as a state or a trait variable in depression, but anhedonia is a multifaceted construct and, as we better understand anhedonia, we increase our ability to measure and treat it. With the aim of personalizing medicine for more efficacious treatments, this paper focuses on clinical patterns we have seen in anhedonic TRD and argues for studies to be done in support of translational, face, and construct validity. Three representative clinical presentations of TRD with anhedonia are described: a congenital type, a stress-induced type, and a type exacerbated by medication. Each case is followed with discussion relating the clinical features to clinical and preclinical research relevant to putative mechanisms for the case. Animal models that are best suited to investigate and validate the existence of etiologies and mechanisms underlying anhedonia constructs unique to each case are proposed, as are potential directions for research in humans.
科研通智能强力驱动
Strongly Powered by AbleSci AI