铃木反应
化学
芳基
DNA
组合化学
钯
纳米技术
催化作用
有机化学
生物化学
材料科学
烷基
作者
Pratik Rajesh Chheda,Nicholas Simmons,David P. Schuman,Zhicai Shi
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-07-13
卷期号:24 (28): 5214-5219
被引量:3
标识
DOI:10.1021/acs.orglett.2c02113
摘要
Developing new DNA-compatible reactions is key to expanding the accessible chemical space of DNA-encoded library (DEL) technology. Here we disclose the first report of a DNA-compatible carbonylative Suzuki coupling of DNA-conjugated (hetero)aryl iodides with (hetero)aryl boronic acids to access di(hetero)aryl ketones, a valuable structural motif present within several approved or clinically advanced small molecules. The reported DNA-compatible, Pd(OAc)2-mediated system is mild, uses a robust protocol, has a wide substrate scope for both coupling partners, is suitable for large-scale DEL productions, and provides a source of previously unexplored chemical matter for DEL screens.
科研通智能强力驱动
Strongly Powered by AbleSci AI