相关性
蒙特利尔认知评估
白质
临床痴呆评级
磁共振弥散成像
心理学
认知障碍
神经心理学
痴呆
认知
神经科学
核医学
内科学
医学
疾病
磁共振成像
数学
几何学
放射科
作者
Xia Xu,Song Xu,Han Lai,Xufeng Yao
出处
期刊:Mathematical Biosciences and Engineering
[American Institute of Mathematical Sciences]
日期:2022-01-01
卷期号:19 (9): 8963-8974
被引量:1
摘要
<abstract> <p>The coupling between functional and structural brain networks is difficult to clarify due to the complicated alterations in gray matter and white matter for the development of Alzheimer's disease (AD). A cohort of 112 participants [normal control group (NC, 62 cases), mild cognitive impairment group (MCI, 31 cases) and AD group (19 cases)], was recruited in our study. The brain networks of rsfMRI functional connectivity (rsfMRI-FC) and diffusion tensor imaging structural connectivity (DTI-SC) across the three groups were constructed, and their correlations were evaluated by Pearson's correlation analyses and multiple comparison with Bonferroni correction. Furthermore, the correlations between rsfMRI-SC/DTI-FC coupling and four neuropsychological scores of mini-mental state examination (MMSE), clinical dementia rating-sum of boxes (CDR-SB), functional activities questionnaire (FAQ) and montreal cognitive assessment (MoCA) were inferred by partial correlation analyses, respectively. The results demonstrated that there existed significant correlation between rsfMRI-FC and DTI-SC (<italic>p</italic> < 0.05), and the coupling of rsfMRI-FC/DTI-SC showed negative correlation with MMSE score (<italic>p</italic> < 0.05), positive correlations with CDR-SB and FAQ scores (<italic>p</italic> < 0.05), and no correlation with MoCA score (<italic>p</italic> > 0.05). It was concluded that there existed FC/SC coupling and varied network characteristics for rsfMRI and DTI, and this would provide the clues to understand the underlying mechanisms of cognitive deficits of AD.</p> </abstract>
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