光热治疗
光动力疗法
纳米颗粒
材料科学
纳米材料
纳米技术
活性氧
体内
光热效应
光化学
化学
生物化学
生物
生物技术
有机化学
作者
Yiming Ding,Zhuo Wang,Zeyu Zhang,Yunchao Zhao,Shangyu Yang,Yalong Zhang,Shuncheng Yao,Shaobo Wang,Tian Huang,Yang Zhang,Linlin Li
出处
期刊:Nano Research
[Springer Nature]
日期:2022-05-10
卷期号:15 (8): 7304-7312
被引量:20
标识
DOI:10.1007/s12274-022-4336-0
摘要
With the rapid development of photo-responsive nanomaterials, photo-triggered therapeutic strategies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have been new alternatives to current cancer therapeutic methods. Herein, we have fabricated oxygen vacancy-engineered BaTiO3 (BTO-Ov) nanoparticles (NPs) for near-infrared (NIR) light-triggered PTT, PDT, and catalytic therapy cooperatively for significantly improving cancer therapy. Compared to pristine BaTiO3 nanoparticles, BTO-Ov has stronger NIR light absorption and narrower band gap structure, which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT. Meanwhile, due to the existence of Ti3+, BTO-Ov also exhibits peroxidase (POD)-like activity to produce hydroxyl radical under tumor environment, which can be further improved under 808 nm light irradiation. Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation. The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform.
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