医学
移植
经济短缺
重症监护医学
乙型肝炎病毒
人类免疫缺陷病毒(HIV)
疾病
免疫学
肝移植
器官移植
作者
Francesco Paolo Russo,Mauro Viganò,Peter Stock,Alberto Ferrarese,Nicola Pugliese,Patrizia Burra,Alessio Aghemo
标识
DOI:10.1016/j.jhep.2022.03.007
摘要
Organ transplantation is a life-saving treatment for patients with end-stage organ disease, a severe condition associated with a high risk of waitlist mortality. It is primarily limited by a shortage of available organs. Maximising available donors can increase access to transplantation. Transplantation from donors positive for HBV and HIV has increased in many countries. However, antiviral therapies need to be readily available for recipients after transplantation to prevent possible reactivation of the virus following the administration of immunosuppressive therapies. Furthermore, the intentional transmission of a virus has practical, ethical, and clinical implications. In this review, we summarise the current research, focusing on grafts from donors positive for the HBV surface antigen, antibodies against the HBV core antigen, and HIV, to help hepatologists and physicians interested in transplantation to select the best antiviral and/or prophylactic regimens for after transplantation.
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