医学
肠系膜
肠系膜动脉
肠系膜上动脉
采样(信号处理)
动脉
病理
放射科
外科
计算机科学
计算机视觉
滤波器(信号处理)
作者
Marcia E. Pereira Bacares
标识
DOI:10.1177/0192623316667245
摘要
Vascular injury can be induced by different classes of drug candidates, and it can affect the mesenteric vasculature. Sampling of the mesenteric vessels in the rat is crucial for proper assessment of potential adverse or pharmacologic effects of drugs in nonclinical rodent studies. To date, several sampling and processing techniques for the histopathologic evaluation of the mesenteric artery in rodents have been described and used in studies with candidate drugs that may affect the vascular system. However, most of those techniques require a significant amount of time and effort. A less labor-intensive, time-consuming, and expensive technique that allows examination of the mesentery vasculature with abundant longitudinal and cross sections of the vessels when examined microscopically was developed and presented here.
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