Targeting Circulating FABP4 Ameliorates Obesity-Associated Hepatic Steatosis

Hepatocytic accumulation of extrinsic FABP4 links adiposity to liver lipid deposition.Specific deletion of FABP4 in adipocytes prevents hepatic steatosis without affecting systemic lipid levels or obesity.Circulating FABP4 derived from adipocytes directly binds hepatocytes to facilitate free fatty acid transfer.Blocking circulating FABP4 with a high-affinity anti-FABP4 monoclonal antibody inhibits hepatocyte lipid uptake and attenuates steatosis in multiple obese mouse models.