医学
他扎罗汀
二氧化碳激光器
显著性差异
皮肤病科
内科学
激光器
激光手术
光学
物理
银屑病
作者
Essam Bakr Abd El-Aal,Hamed Mohamed Abdo,Samir Ibrahim,Mostafa Taha Eldestawy
标识
DOI:10.1080/09546634.2018.1509046
摘要
Background: Onychomycosis is a chronic fungal infection of the nails, and the treatment has been proven to be a challenge to healthcare professionals.Objective: To evaluate the efficacy of fractional carbon dioxide laser-assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.Materials and Methods: A total of 102 patients with onychomycosis were randomly assigned to groups A and B, and both groups were treated with four sessions of fractional CO2 laser and followed by topical tazarotene 0.1% in Group A and topical tioconazole 28% in Group B. The clinical effect, KOH examination, and culture for the affected nails in the two groups were analyzed.Results: One month after the last session, regarding clinical response, 35.3% showed complete improvement in Group A versus 33.3% in Group B without significant difference. There was a significant difference between the two studied groups as regards KOH test and culture result before and after treatment (p value<.001), they were turned negative in 91.7% and 100% of patients in Group A and 78.3% and 95.5% of patients in Group B, respectively.Conclusion: Fractional CO2 laser-assisted drug delivery is an effective and safe treatment option for onychomycosis.
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