蛋白激酶B
PI3K/AKT/mTOR通路
细胞生长
癌症研究
细胞生物学
细胞周期
癌基因
细胞
骨肉瘤
细胞迁移
生物
基因敲除
信号转导
磷酸肌醇3激酶
细胞培养
遗传学
作者
Qing‐Zhi Gu,Nijiati Abulimiti,Xing Gao,Kai‐Liang Tao,Cheng‐Duo Li,Xuepeng Fan,Tao Zheng
出处
期刊:Molecular Medicine Reports
[Spandidos Publications]
日期:2018-05-29
被引量:15
标识
DOI:10.3892/mmr.2018.9083
摘要
Human trophoblast cell surface antigen 2 (TROP2) has been noted to serve an important role in the proliferation and migration of various types of human cancers. However, the potential role and the molecular mechanisms of TROP2 in osteosarcoma (OS) remain largely unclear. In the present study, high expression of TROP2 in human OS tissues and cell lines was observed. Overexpression of TROP2 promoted the proliferation and migration of OS cell lines, while TROP2 knockdown markedly decreased cell growth and migration. Furthermore, it was revealed that TROP2 overexpression significantly activated the phosphoinositide 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway. Collectively, these results suggested that TROP2 may promote OS cell proliferation and migration via PI3K/AKT signaling and may serve as a novel treatment target for OS.
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