医学
库欣病
疾病
重症监护医学
促肾上腺皮质激素
库欣综合征
垂体腺瘤
多毛症
高皮质醇血症
儿科
腺瘤
肥胖
内科学
激素
胰岛素抵抗
多囊卵巢
作者
Anca Buliman,Tataranu Lg,Păun Dl,Alexandra Mirică,Constantin Dumitrache
出处
期刊:PubMed
日期:2016-12-16
卷期号:9 (1): 12-18
被引量:14
摘要
Cushing's disease is considered a rare condition characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. The clinical signs suggesting Cushing's disease, such as obesity, moon face, hirsutism, and facial plethora are already present on presentation. Endogenous hypercortisolism is associated with an increased risk of cardiovascular and metabolic manifestations, as well as respiratory disorders, psychiatric complications, osteoporosis and infections, leading to high rates of morbidity and mortality. It is vital to diagnose Cushing's disease as early as possible and to implement a treatment plan to lead to a successful prognosis and a low number of complications. The goal of this article was to review the clinical, diagnostic and treatment aspects of Cushing's disease using the most recent available guidelines.
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