大肠杆菌
红霉素
核酸
抗菌剂
细菌
抗生素耐药性
化学
药物输送
抗生素
微生物学
乳酸乳球菌
生物物理学
生物化学
生物
有机化学
基因
乳酸
遗传学
作者
Yue Sun,Yu-Hao Liu,Bowen Zhang,Shirong Shi,Tao Zhang,Dan Zhao,Taoran Tian,Qirong Li,Yunfeng Lin
标识
DOI:10.1016/j.bioactmat.2020.12.027
摘要
Erythromycin is a commonly used broad-spectrum antibiotic, but resistance to this antibiotic makes its use less effective. Considerable efforts, beside finding alternatives, are needed to enhance its antimicrobial effect and stability against bacteria. Tetrahedral framework nucleic acids (tFNAs), a novel delivery vehicle with a three-dimensional nanostructure, have been studied as a carrying platform of antineoplastic drugs. In this study, the use of tFNAs in delivering erythromycin into Escherichia coli (E. coli) was investigated for the first time. The tFNAs vehicle increased the bacterial uptake of erythromycin and promoted membrane destabilization. Moreover, it increased the permeability of the bacterial cell wall, and reduced drug resistance by improving the movement of the drug across the membrane. The tFNAs-based delivery system enhanced the effects of erythromycin against E. coli. It may therefore provide an effective delivery vehicle for erythromycin in targeting antibiotic-resistant bacteria with thick cell wall.
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