[Genes and molecular mechanisms affecting the correlation between liver cancer and diabetes mellitus].

Hepatocellular carcinoma (HCC) is a common and high incidence disease in China. It is presently thought that diabetes is one of the independent risk factor for HCC. Diabetes and liver cancer are closely related, but the relationship and mechanism of diabetes and liver cancer are quite complex and controversial. Insulin resistance, glucose metabolism and lipid metabolism disorders, and abnormal release of inflammatory mediators are the common bases of these two diseases. The molecular mechanisms of glycogen synthase kinase-3, toll like receptor 4, CCL5, CXCL14 and NCOA5, TCF7L2 genes affecting the correlation between liver cancer and diabetes mellitus are discussed and explained to provide the basis for the study and treatment of disease.肝细胞肝癌是我国的常见病、多发病，目前认为，糖尿病是肝癌的独立危险因素之一。糖尿病与肝癌关系密切，但糖尿病与肝癌发生的关系和机制相当复杂，尚存在争论。胰岛素抵抗、糖代谢及脂质代谢紊乱、炎性介质异常释放等是这两种疾病的共同发病基础。现通过探讨核受体助激活蛋白5、TCF7L2、糖原合成酶3、Toll样受体4、趋化因子CCL5和CXCL14基因对糖尿病及肝癌的影响，阐释两种疾病的共同发病机制关联，为疾病的研究及治疗提供依据。.