褪黑素
雌激素受体
乳腺癌
交易激励
褪黑激素受体
内分泌学
内科学
生物
癌症研究
癌症
转移
雌激素
癌细胞
医学
基因表达
基因
生物化学
作者
Xiangyi Kong,Ran Gao,Zhongzhao Wang,Xiangyu Wang,Yi Fang,Jun Gao,Russel J. Reíter,Jing Wang
标识
DOI:10.1016/j.tem.2020.08.001
摘要
Melatonin has significant inhibitory effects in numerous cancers, especially breast cancer. In estrogen receptor (ER)-positive human breast cancer, the oncostatic actions of melatonin are mainly achieved by suppressing ER mRNA expression and ER transcriptional activity via the MT1 receptor. Melatonin also regulates the transactivation of nuclear receptors, estrogen-metabolizing enzymes, and the expression of related genes. Furthermore, melatonin suppresses tumor aerobic glycolysis, critical cell-signaling pathways relevant to cell proliferation, survival, metastasis, and overcomes drug resistance. Studies in animal and human models indicate that disruption of the circadian nocturnal melatonin signal promotes the growth, metabolism, and signaling of human breast cancer, resulting in resistance to hormone therapy and chemotherapy, which may be reversed by melatonin.
科研通智能强力驱动
Strongly Powered by AbleSci AI