Competitive Efficiency of Local Application Hemostatic Agents in Experimental Parenchymatous and Arterial Bleeding Control

Relevance  Bleeding control in case of injury and surgery on parenchymatous organs and blood vessels is a serious challenge for surgery. Use of local application hemostatic agents is an innovative solution. Such agents are represented in Russia by foreign producers and Russian developments, but comparative evaluation of their efficiency is poorly known, that makes such research highly relevant. The purpose of the study  To compare efficiency of the Russian application hemostatic agent «Hemoflex® Pro» with foreign analogues on the models of parenchymatous and arterial bleeding. Materials and methods  Comparative efficiency analysis of hemostatic agent «Hemoflex® Pro» (LLC Inmed, RF) and agents «Surgicel® Nu-knit» (Johnson & Johnson, USA), «TachoComb®» (Nycomed Austria GmbH, Austria), «CeloxТМ Gauze Hemostat» (MedTrade Products Ltd, Great Britain) was carried out on the model of experimental parenchymatous and arterial bleeding of rats. Results and their discussion  Conducted comparative analysis of hemostatic agents in experiment on animals shows close time values of bleeding and blood loss of Russian and foreign application hemostatic agents by simulation of experimental parenchymatous bleeding. The agent «Hemoflex® Pro» showed better hemostatic effect by simulation of experimental arterial bleeding from a wound in aorta abdominal region. It also proved bactericidal action of «Hemoflex® Pro», its rapid bio degradation, lack of influence on formation of adhesive process in case of its use in abdominal region. Conclusion  Research marked similar hemostatic effect comparing action of «Hemoflex® Pro» with hemostatic agents «Surgicel® Nu-knit», «TachoComb®» and «CeloxТМ Gauze Hemostat». Moreover it registered bactericidal action of hemostatic agent «Hemoflex® Pro» against E.coli, S.aureus, S.pyogenes, C.albicans, Myc. smegmatis.