免疫
炎症
免疫系统
生物
细胞生物学
转录因子
先天免疫系统
免疫抑制
免疫学
获得性免疫系统
基因
遗传学
作者
Anne F. McGettrick,Luke A.J. O’Neill
标识
DOI:10.1016/j.cmet.2020.08.002
摘要
Summary
HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization can also occur under normoxia during immunity and inflammation, where it regulates metabolism but in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors.
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