黑色素瘤
细胞毒性T细胞
免疫疗法
免疫系统
细胞溶解
癌症研究
免疫学
医学
淋巴因子激活杀伤细胞
肿瘤浸润淋巴细胞
过继性细胞移植
生物
体外
T细胞
白细胞介素21
生物化学
作者
Linda Muul,Paul J. Spiess,E P Director,S A Rosenberg
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1987-02-01
卷期号:138 (3): 989-995
被引量:425
标识
DOI:10.4049/jimmunol.138.3.989
摘要
Abstract Tumor-infiltrating lymphocytes from six patients with metastatic malignant melanoma were expanded by culture in recombinant interleukin 2. Three of the preparations were highly cytotoxic against autologous fresh melanoma tumor cells, but not against autologous fresh normal cells or allogeneic fresh tumor targets. The other three were highly cytotoxic against autologous fresh melanoma tumor cells and also had a limited capacity to kill allogeneic fresh tumor targets. The tumor-associated specific killer cells could be expanded from threefold to 95,652-fold with maintenance of specific antitumor lysis. The expanded tumor-infiltrating cells were Leu-4+ T cells, and in five of six patients the majority were Leu-3+. These studies demonstrate that the melanoma-bearing patient raises an immune response against autologous tumor and presents a method for the generation of human lymphocytes with antitumor reactivity that may be useful in the adoptive immunotherapy of tumors.
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