医学
胆固醇
入射(几何)
内科学
队列
队列研究
疾病
内分泌学
数学
几何学
作者
Tomonori Okamura,Yoshihiro Kokubo,Makoto Watanabe,Aya Higashiyama,Yoshihiro Miyamoto,Yasunao Yoshimasa,Akira Okayama
出处
期刊:Atherosclerosis
[Elsevier]
日期:2009-04-01
卷期号:203 (2): 587-592
被引量:110
标识
DOI:10.1016/j.atherosclerosis.2008.07.020
摘要
Abstract
Objective
Only a small number of population-based cohort studies have directly compared the predictive value of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDLC) for coronary artery disease in Asian populations, such as Japan. Methods
We performed an 11.9-year cohort study of 4694 men and women, aged 30–74 years, selected randomly from an urban general population in Japan. Baseline LDL-C levels were estimated using the Friedewald formula. The predictive values of LDL-C and non-HDLC for myocardial infarction (MI) and stroke were compared. Results and conclusion
During the follow-up period, there were 80 incident cases of MI and 139 of stoke, comprised of 23 intracerebral hemorrhages, 85 cerebral infarctions and 31 other types of stroke. The Hazard ratio (HR) for MI was highest in the top quintile of LDL-C (HR: 3.03, 95% CI, 1.32–6.96) when male and female data were combined. The HR for MI was also highest in the top quintile of non-HDLC (HR: 2.97, 95% CI, 1.26–6.97). Analysis of trends showed a significant positive relationship between MI incidence and serum LDL-C and non-HDLC levels (both P=0.02). However, there was no relationship between the incidence of any subtype of stroke and either LDL-C or non-HDLC. The predictive value of LDL-C and non-HDLC for MI, assessed by calculating the differences in the −2 logarithm likelihood (−2ln [L]) and area under the curve (AUC), were almost similar.
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