细胞凋亡
体外
多糖
细胞培养
化学
海带
线粒体
细胞生物学
生物
分子生物学
生物化学
植物
藻类
遗传学
作者
Zhenfei Peng,Min Liu,Zhexiang Fang,Li Chen,Jiulin Wu,Qiqing Zhang
标识
DOI:10.1016/j.fct.2013.04.026
摘要
A water-soluble polysaccharide WPS-2-1, purified from Laminaria japonica, has been found to have antitumor activity. In this study, WPS-2-1 exhibited high anti-proliferative activity on A375 cells in a dosedependent manner. Further investigation indicated that WPS-2-1 induced A375 cells apoptosis. Moreover, WPS-2-1-induced apoptosis was associated with the alteration in expressions of Bcl-2 family proteins. Mitochonadrial apoptotic pathway was involved in WPS-2-1-induced apoptosis, which included the loss of mitochondrial membrane and activation of caspase-3/9. The results in this study suggested that WPS-2-1 could effectively inhibit proliferation of A375 cells in vitro and induce apoptosis via mitochondrial apoptotic pathway. It might serve as a potential antitumor agent.
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