MP60-19 THE ASSOCIATION BETWEEN METABOLIC SYNDROME AND ADVANCED PROSTATE CANCER IN CHINESE PATIENTS RECEIVING RADICAL PROSTATECTOMY

You have accessJournal of UrologyProstate Cancer: Detection and Screening II1 Apr 2015MP60-19 THE ASSOCIATION BETWEEN METABOLIC SYNDROME AND ADVANCED PROSTATE CANCER IN CHINESE PATIENTS RECEIVING RADICAL PROSTATECTOMY Guiming Zhang, Yao Zhu, Dahai Dong, Chengtao Han, Chengyuan Gu, Weijie Gu, Xiaojian Qin, Lijiang Sun, and Dingwei Ye Guiming ZhangGuiming Zhang More articles by this author , Yao ZhuYao Zhu More articles by this author , Dahai DongDahai Dong More articles by this author , Chengtao HanChengtao Han More articles by this author , Chengyuan GuChengyuan Gu More articles by this author , Weijie GuWeijie Gu More articles by this author , Xiaojian QinXiaojian Qin More articles by this author , Lijiang SunLijiang Sun More articles by this author , and Dingwei YeDingwei Ye More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2221AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The global incidence of metabolic syndrome (MetS) is dramatically increasing. Considerable interest has been devoted to the relationship between MetS and prostate cancer (PCa) risk. However, few studies have examined the association between MetS and PCa progression. METHODS This retrospective study consisted of 1,016 patients with PCa who received radical prostatectomy. The association between MetS and pathological features was evaluated using logistic regression analysis. RESULTS Compared with patients without MetS, those with MetS indicated an increased risk of prostatectomy Gleason score (GS) ¡Ý8 (odds ratio (OR) = 1.670, 95% confidence interval (CI) 1.096-2.545, P=0.017), and a 1.5-fold increased risk of pT3-4 disease (OR = 1.583, 95%CI 1.106-2.266, P=0.012). The presence of MetS was an independent predictor of lymph node involvement (OR = 1.751, 95%CI 1.038-2.955, P=0.036). Furthermore, as the number of MetS components accumulated, the risk of a GS ¡Ý8 increased. CONCLUSIONS The present study indicates a significant association between MetS and advanced PCa. The results need to be evaluated in large-scale prospective cohorts. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e746 Peer Review Report Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Guiming Zhang More articles by this author Yao Zhu More articles by this author Dahai Dong More articles by this author Chengtao Han More articles by this author Chengyuan Gu More articles by this author Weijie Gu More articles by this author Xiaojian Qin More articles by this author Lijiang Sun More articles by this author Dingwei Ye More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...