生物
表观遗传学
计算生物学
转录组
基因组学
有机体
基因组
遗传学
DNA甲基化
基因
基因表达
作者
Iain C. Macaulay,Thierry Voet
出处
期刊:PLOS Genetics
日期:2014-01-30
卷期号:10 (1): e1004126-e1004126
被引量:336
标识
DOI:10.1371/journal.pgen.1004126
摘要
Advances in whole-genome and whole-transcriptome amplification have permitted the sequencing of the minute amounts of DNA and RNA present in a single cell, offering a window into the extent and nature of genomic and transcriptomic heterogeneity which occurs in both normal development and disease. Single-cell approaches stand poised to revolutionise our capacity to understand the scale of genomic, epigenomic, and transcriptomic diversity that occurs during the lifetime of an individual organism. Here, we review the major technological and biological breakthroughs achieved, describe the remaining challenges to overcome, and provide a glimpse into the promise of recent and future developments.
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